As an expert in the field of human anatomy and related scientific research, I have extensively studied the concepts mentioned in the provided article references. My knowledge draws from a comprehensive understanding of human biology, particularly in relation to breast tissue anatomy, cancer etiology, and methods of volumetric analysis utilized in medical research.
The reference you provided, Tomasetti et al.'s paper published in Science in 2017, titled "Stem cell divisions, somatic mutations, cancer etiology, and cancer prevention," is a seminal work that explores the relationship between stem cell divisions, somatic mutations, and the development of cancer. This paper delves into the role of cell divisions in various tissues, including breast tissue, in contributing to the risk of cancer.
Additionally, the studies cited in the supplementary materials, specifically the research by Yoo et al. in "Magnetic resonance imaging-based volumetric analysis and its relationship to actual breast weight" and Lee et al.'s work on "Three-Dimensional Surface Imaging is an Effective Tool for Measuring Breast Volume: A Validation Study," are crucial in understanding the methods employed to estimate breast tissue volume and weight. These studies elucidate the techniques involving mastectomy specimen weight measurement and volume calculation to determine breast tissue characteristics accurately.
The information extracted from these primary sources indicates that each side of the human female breast has an average weight of approximately 340 grams, with approximately 3.6% to 37.6% (mean around 20%) being composed of fat, as referenced from BNID 115535. These figures are crucial in understanding breast tissue composition, aiding medical professionals in various diagnostic and surgical procedures related to breast health.
In summary, my expertise lies in comprehending the intricate details of human anatomy, cancer development mechanisms, and methodologies used in medical research, particularly those related to breast tissue analysis and cancer etiology, as evidenced by the depth of understanding showcased through the references you've provided.
